English Statistics Help FAQ Contact Us
Download >>

PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.

Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>
2a4g.jpg
More images...
View in 3D molecule viewer
( jV4 / Jmol ) *1
PDB ID2a4g  sequence information (FASTA format)   
DescriptorNS3 protease/helicase, NS4a peptide
TitleHepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound
Functional KeywordsViral Protein
Biological sourceHepatitis C virus
Total number of polymer chains4
Total molecular weight48072.4 (the details in Structural Details Page)
AuthorsArasappan, A. , Njoroge, F.G. , Chan, T.Y. , Bennett, F. , Bogen, S.L. , Chen, K. , Gu, H. , Hong, L. , Jao, E. , Liu, Y.T. , Lovey, R.G. , Parekh, T. , Pike, R.E. , Pinto, P. , Santhanam, B. , Venkatraman, S. , Vaccaro, H. , Wang, H. , Yang, X. , Zhu, Z. , Mckittrick, B. , Saksena, A.K. , Girijavallabhan, V. , Pichardo, J. , Butkiewicz, N. , Ingram, R. , Malcolm, B. , Prongay, A.J. , Yao, N. , Marten, B. , V., Madison , Kemp, S. , Levy, O. , Lim-Wilby, M. , Tamura, S. , Ganguly, A.K. (deposition date : 2005-06-28, release date : 2006-07-04)
Primary citationArasappan, A. , Njoroge, F.G. , Chan, T.Y. , Bennett, F. , Bogen, S.L. , Chen, K. , Gu, H. , Hong, L. , Jao, E. , Liu, Y.T. , Lovey, R.G. , Parekh, T. , Pike, R.E. , Pinto, P. , Santhanam, B. , Venkatraman, S. , Vaccaro, H. , Wang, H. , Yang, X. , Zhu, Z. , Mckittrick, B. , Saksena, A.K. , Girijavallabhan, V. , Pichardo, J. , Butkiewicz, N. , Ingram, R. , Malcolm, B. , Prongay, A.J. , Yao, N. , Marten, B. , Madison, V. , Kemp, S. , Levy, O. , Lim-Wilby, M. , Tamura, S. , Ganguly, A.K.
Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Bioorg.Med.Chem.Lett., 15:4180 - 4184, 2005.(PubMed : 16087332)  (DOI: 10.1016/j.bmcl.2005.06.091)
Experimental methodX-RAY DIFFRACTION ( 2.50[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , GenBank/DDBJ/EMBL (GB - 28921568, GB - 51039195) , eF-site , PISA , PDB/RDF



*1) jV4 and Jmol require Java(TM)Plug-in 1.5 or later.
     Currently, you can't browse web pages which include jV applets in some version of Mac OS X. See here for more details.