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MineSummary [1a85]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>
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PDB ID1a85  sequence information (FASTA format)   
RELATED PRD_IDPRD_000249
DescriptorMMP-8, 2-HYDROXYCARBAMOYL-4-METHYL-PENTANOIC ACID, ASPARAGINE, 1,3-DIAMINOBENZYL PHENYLALANINE
TitleMMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR
Functional KeywordsCOLLAGENASE, MATRIX METALLOPROTEINASE, MALONIC ACID, MMP8, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
HYDROLASE/HYDROLASE INHIBITOR
Biological sourceHomo sapiens (human)
Cellular location [UNP - P22894] Cytoplasmic granule
Organ source [UNP - P22894] Neutrophil
[UNP - P22894] Lung
Total number of polymer chains1
Total molecular weight18216.7 (the details in Structural Details Page)
AuthorsBrandstetter, H. , Roedern, E.G.V. , Grams, F. , Engh, R.A. (deposition date : 1998-04-03, release date : 1999-04-27, last modified : 2011-07-13)
Primary citationBrandstetter, H. , Engh, R.A. , Von Roedern, E.G. , Moroder, L. , Huber, R. , Bode, W. , Grams, F.
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
Protein Sci., 7:1303 - 1309, 1998.(PubMed : 9655333)
Experimental methodX-RAY DIFFRACTION ( 2.0[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P22894 ) , eF-site , KEGG (EC 3.4.24.34 ) , PISA , wwPDB/RDF


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