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MineSummary [1dqa]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>
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PDB ID1dqa  sequence information (FASTA format)   
DescriptorHUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+
TitleCOMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+
Functional KeywordsOXIDOREDUCTASE, CHOLESTEROL BIOSYNTHESIS, HMG-COA, NADPH
Biological sourceHomo sapiens (human)
Cellular location [UNP - P04035] Endoplasmic reticulum membrane; Multi-pass membrane protein
Organ source [UNP - P04035] Blood
Total number of polymer chains4
Total molecular weight206779.6 (the details in Structural Details Page)
AuthorsIstvan, E.S. , Palnitkar, M. , Buchanan, S.K. , Deisenhofer, J. (deposition date : 1999-12-30, release date : 2000-03-08, last modified : 2009-02-24)
Primary citationIstvan, E.S. , Palnitkar, M. , Buchanan, S.K. , Deisenhofer, J.
Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
EMBO J., 19:819 - 830, 2000.(PubMed : 10698924)  (DOI: 10.1093/emboj/19.5.819)
Experimental methodX-RAY DIFFRACTION ( 2.00[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P04035 ) , eF-site , KEGG (EC 1.1.1.34 ) , PISA , wwPDB/RDF


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