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<Asymmetric unit>
= <Biological unit>
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PDB ID1klg  sequence information (FASTA format)   
RELATED PDB ID1klu
DescriptorHLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA AND BETA CHAINS/ENTEROTOXIN TYPE C-3/Triosephosphate isomerase peptide complex
TitleCrystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
Functional KeywordsHLA-DR1/TPI, enterotoxin C3, human melanoma antigen, CD4+ T cells, IMMUNE SYSTEM-TOXIN COMPLEX
IMMUNE SYSTEM/TOXIN
Biological sourceHomo sapiens (human) ,Staphylococcus aureus (the details in Structural Details Page)
Cellular location [UNP - P01903] Cell membrane; Single-pass type I membrane protein
[UNP - P0A0L5] Secreted
Organ source [UNP - P01903] Blood, and Colon
[UNP - P01903] B-cell
[UNP - P01903] Blood
[UNP - P01903] Liver
[UNP - P04229] Cerebellum
Total number of polymer chains4
Total molecular weight71882.3 (the details in Structural Details Page)
AuthorsSundberg, E.J. , Sawicki, M.W. , Andersen, P.S. , Sidney, J. , Sette, A. , Mariuzza, R.A. (deposition date : 2001-12-11, release date : 2002-08-02, last modified : 2009-02-24)
Primary citationSundberg, E.J. , Sawicki, M.W. , Southwood, S. , Andersen, P.S. , Sette, A. , Mariuzza, R.A.
Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.
J.Mol.Biol., 319:449 - 461, 2002.(PubMed : 12051920)  (DOI: 10.1016/S0022-2836(02)00370-4)
Experimental methodX-RAY DIFFRACTION ( 2.40[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01903, P04229, P0A0L5 ) , eF-site , PISA , wwPDB/RDF



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