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<Asymmetric unit>
= <Biological unit>
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PDB ID1o47  sequence information (FASTA format)   
DescriptorPROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE
TitleCRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209.
Functional KeywordsSH2 DOMAIN FRAGMENT APPROACH, SIGNALING PROTEIN
Biological sourceHomo sapiens (human)
Cellular location [UNP - P12931] Cell membrane
Organ source [UNP - P12931] Lung, and Skin
[UNP - P12931] Lung carcinoma
[UNP - P12931] Leukemic T-cell
[UNP - P12931] Platelet
[UNP - P12931] Cervix carcinoma
[UNP - P12931] Mammary epithelium
Total number of polymer chains1
Total molecular weight12988.7 (the details in Structural Details Page)
AuthorsLange, G. , Loenze, P. , Liesum, A. (deposition date : 2003-06-15, release date : 2004-02-17, last modified : 2009-02-24)
Primary citationLange, G. , Lesuisse, D. , Deprez, P. , Schoot, B. , Loenze, P. , Benard, D. , Marquette, J.P. , Broto, P. , Sarubbi, E. , Mandine, E.
Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46:5184 - 5195, 2003.(PubMed : 14613321)  (DOI: 10.1021/jm020970s)
Experimental methodX-RAY DIFFRACTION ( 1.80[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P12931 ) , eF-site , KEGG (EC 2.7.1.112 ) , PISA , wwPDB/RDF



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