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MineSummary [1tnf]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>
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PDB ID1tnf  sequence information (FASTA format)   
DescriptorTUMOR NECROSIS FACTOR-ALPHA (CACHECTIN)
TitleTHE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING
Functional KeywordsLYMPHOKINE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P01375] Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted
Organ source [UNP - P01375] Blood
[UNP - P01375] Prostatic carcinoma
Total number of polymer chains3
Total molecular weight52106.7 (the details in Structural Details Page)
AuthorsEck, M.J. , Sprang, S.R. (deposition date : 1989-08-25, release date : 1990-01-15, last modified : 2009-02-24)
Primary citationEck, M.J. , Sprang, S.R.
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
J.Biol.Chem., 264:17595 - 17605, 1989.(PubMed : 2551905)
Experimental methodX-RAY DIFFRACTION ( 2.6[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01375 ) , eF-site , PISA , wwPDB/RDF


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