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MineSummary [2c7v]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>
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PDB ID2c7v  sequence information (FASTA format)   
DescriptorPTERIDINE REDUCTASE (E.C.1.5.1.33)
TitleSTRUCTURE OF TRYPANOSOMA BRUCEI PTERIDINE REDUCTASE (PTR1) IN TERNARY COMPLEX WITH COFACTOR AND THE ANTIFOLATE METHOTREXATE
Functional KeywordsPTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
Biological sourceTRYPANOSOMA BRUCEI BRUCEI
Total number of polymer chains4
Total molecular weight119981 (the details in Structural Details Page)
AuthorsDawson, A. , Gibellini, F. , Sienkiewicz, N. , Fyfe, P.K. , Mcluskey, K. , Fairlamb, A.H. , Hunter, W.N. (deposition date : 2005-11-29, release date : 2006-09-19, last modified : 2009-02-24)
Primary citationDawson, A. , Gibellini, F. , Sienkiewicz, N. , Tulloch, L.B. , Fyfe, P.K. , Mcluskey, K. , Fairlamb, A.H. , Hunter, W.N.
Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate
Mol.Microbiol., 61:1457 - , 2006.(PubMed : 16968221)  (DOI: 10.1111/J.1365-2958.2006.05332.X)
Experimental methodX-RAY DIFFRACTION ( 2.20[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( O76290 ) , eF-site , KEGG (EC 1.5.1.33 ) , PISA , wwPDB/RDF


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