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<Asymmetric unit>
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PDB ID2f4j  sequence information (FASTA format)   
DescriptorProto-oncogene tyrosine-protein kinase ABL1 (E.C.2.7.1.112)
TitleStructure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Functional Keywordskinase, kinase inhibitor, abl, TRANSFERASE
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight33636.8 (the details in Structural Details Page)
AuthorsYoung, M.A. , Shah, N.P. , Chao, L.H. , Zarrinkar, P. , Sawyers, P. , Kuriyan, J. (deposition date : 2005-11-23, release date : 2006-01-24, last modified : 2009-02-24)
Primary citationYoung, M.A. , Shah, N.P. , Chao, L.H. , Seeliger, M. , Milanov, Z.V. , Biggs, W.H. , Treiber, D.K. , Patel, H.K. , Zarrinkar, P.P. , Lockhart, D.J. , Sawyers, C.L. , Kuriyan, J.
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
Cancer Res., 66:1007 - 1014, 2006.(PubMed : 16424036)  (DOI: 10.1158/0008-5472.CAN-05-2788)
Experimental methodX-RAY DIFFRACTION ( 1.91[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , GenBank/DDBJ/EMBL (GB - 62362414) , eF-site , KEGG (EC 2.7.1.112 ) , PISA , wwPDB/RDF



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