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<Asymmetric unit>
= <Biological unit>
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PDB ID2gh5  sequence information (FASTA format)   
Descriptorglutathione reductase, mitochondrial (E.C.1.8.1.7)
TitleCrystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5
Functional Keywordshuman glutathione reductase; A Fluoro-Analogue of the Menadione Derivative M5, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00390] Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm
Organ source [UNP - P00390] Placenta
[UNP - P00390] Lung
[UNP - P00390] Erythrocyte
Total number of polymer chains2
Total molecular weight106902.6 (the details in Structural Details Page)
AuthorsFritz-Wolf, K. , Winzer, A. , Bauer, H. , Schirmer, H. , Davioud-Charvet, E. (deposition date : 2006-03-25, release date : 2006-09-26, last modified : 2011-07-13)
Primary citationBauer, H. , Fritz-Wolf, K. , Winzer, A. , Little, S. , Yardley, V. , Vezin, H. , Palfey, B. , Schirmer, R.H. , Davioud-Charvet, E.
A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme
J.Am.Chem.Soc., 128:10784 - 10794, 2006.(PubMed : 16910673)  (DOI: 10.1021/ja061155v)
Experimental methodX-RAY DIFFRACTION ( 1.70[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P00390 ) , eF-site , KEGG (EC 1.8.1.7 ) , PISA , wwPDB/RDF



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