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MineSummary [2iug]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>
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PDB ID2iug  sequence information (FASTA format)   
RELATED PDB ID1a0n, 1azg, 1h9o, 1pbw, 1pht, 1pic, 1pks, 1pkt, 2iuh, 2iui
DescriptorPHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
TitleCRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN
Functional KeywordsTRANSFERASE, PHOSPHORYLATION, P85, SH2, PI3K, SH2 DOMAIN, SH3 DOMAIN, PI3-KINASE, DISEASE MUTATION
Biological sourceHOMO SAPIENS (HUMAN)
Organ source [UNP - P27986] Skeletal muscle
[UNP - P27986] Brain
[UNP - P27986] Placenta, and Skeletal muscle
[UNP - P27986] Mammary epithelium
[UNP - P27986] Lung carcinoma
Total number of polymer chains1
Total molecular weight13939.7 (the details in Structural Details Page)
AuthorsNolte, R.T. , Eck, M.J. , Schlessinger, J. , Shoelson, S.E. , Harrison, S.C. (deposition date : 2006-06-03, release date : 2006-06-06, last modified : 2009-02-24)
Primary citationNolte, R.T. , Eck, M.J. , Schlessinger, J. , Shoelson, S.E. , Harrison, S.C.
Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3:364 - , 1996.(PubMed : 8599763)  (DOI: 10.1038/NSB0496-364)
Experimental methodX-RAY DIFFRACTION ( 1.89[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P27986 ) , eF-site , PISA , wwPDB/RDF


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