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PDB ID2ofu  sequence information (FASTA format)   
DescriptorProto-oncogene tyrosine-protein kinase LCK (E.C.2.7.10.2)
Titlex-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck
Functional KeywordsLck, Kinase domain, TRANSFERASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P06239] Cytoplasm
Organ source [UNP - P06239] Leukemia
[UNP - P06239] Leukemic T-cell
[UNP - P06239] Lymph
[UNP - P06239] Peripheral blood lymphocyte
[UNP - P06239] Mammary cancer
[UNP - P06239] Lung carcinoma
[UNP - P06239] Cervix carcinoma
Total number of polymer chains1
Total molecular weight32434.3 (the details in Structural Details Page)
AuthorsHuang, X. (deposition date : 2007-01-04, release date : 2007-02-27, last modified : 2009-02-24)
Primary citationMartin, M.W. , Newcomb, J. , Nunes, J.J. , McGowan, D.C. , Armistead, D.M. , Boucher, C. , Buchanan, J.L. , Buckner, W. , Chai, L. , Elbaum, D. , Epstein, L.F. , Faust, T. , Flynn, S. , Gallant, P. , Gore, A. , Gu, Y. , Hsieh, F. , Huang, X. , Lee, J.H. , Metz, D. , Middleton, S. , Mohn, D. , Morgenstern, K. , Morrison, M.J. , Novak, P.M. , Oliveira-dos-Santos, A. , Powers, D. , Rose, P. , Schneider, S. , Sell, S. , Tudor, Y. , Turci, S.M. , Welcher, A.A. , White, R.D. , Zack, D. , Zhao, H. , Zhu, L. , Zhu, X. , Ghiron, C. , Amouzegh, P. , Ermann, M. , Jenkins, J. , Johnston, D. , Napier, S. , Power, E.
Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
J.Med.Chem., 49:4981 - , 2006.(PubMed : 16884310)  (DOI: 10.1021/jm060435i)
Experimental methodX-RAY DIFFRACTION ( 2.00[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P06239 ) , eF-site , KEGG (EC 2.7.10.2 ) , PISA , wwPDB/RDF



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