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Summary [2zpx]

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PDB ID or Keywordsequenceauthor nameEMDB ID

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<Asymmetric unit> = <Biological unit> More images... View in 3D molecule viewer ( jV4 / Jmol ) *1

PDB ID 2zpx  sequence information (FASTA format)    RELATED PDB ID 1tnf, 1tnr, 2ea7, 2zjc Descriptor Tumor necrosis factor Title TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8 Functional Keywords Tumor necrosis factor, Trimer, Antagonistic activity, TNFR1 specific, Phage display system, Cytokine, Cell membrane, Lipoprotein, Membrane, Myristate, Phosphoprotein, Secreted, Signal-anchor, Transmembrane CYTOKINE Biological source Homo sapiens (Human) Cellular location [UNP - P01375] Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted Organ source [UNP - P01375] Blood [UNP - P01375] Prostatic carcinoma Total number of polymer chains 3 Total molecular weight 51850.8 (the details in Structural Details Page) Authors Mukai, Y. , Nakamura, T. , Yamagata, Y. , Tsutsumi, Y. (deposition date : 2008-07-29, release date : 2009-03-24, last modified : 2009-08-18) Primary citation Mukai, Y. , Nakamura, T. , Yoshioka, Y. , Shibata, H. , Abe, Y. , Nomura, T. , Taniai, M. , Ohta, T. , Nakagawa, S. , Tsunoda, S. , Kamada, H. , Yamagata, Y. , Tsutsumi, Y. Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists J.Biochem., 146:167 - 172, 2009.(PubMed : 19386778)  (DOI: 10.1093/jb/mvp065) Experimental method X-RAY DIFFRACTION ( 2.83[Å] ) Other Database Information EM Navigator , Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01375 ) , eF-site , GDB , ProTherm , EzCatDB , PISA , PQS , wwPDB/RDF

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