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Summary [3en5]

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PDB ID or Keywordsequenceauthor nameEMDB ID

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<Asymmetric unit> More images... View in 3D molecule viewer ( jV4 / Jmol ) *1 <Biological unit> View in 3D molecule viewer ( jV4 ) *1

PDB ID 3en5  sequence information (FASTA format)    RELATED PDB ID 3en4, 3en6, 3en7 Descriptor Proto-oncogene tyrosine-protein kinase Src (E.C.2.7.10.2) Title Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor Functional Keywords SRC, tyrosine, kinase, polypharmacology, inhibitor, multitarget, phosphoinositide, transferase, signaling, pyrazolopyrimidine, kinase-inhibitor complex, ATP-binding, Lipoprotein, Myristate, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Tyrosine-protein kinase TRANSFERASE Biological source Gallus gallus (bantam,chickens) (the details in Structural Details Page) Cellular location [UNP - P00523] Cell membrane (By similarity) Organ source [UNP - P00523] Pectoralis muscle Total number of polymer chains 2 Total molecular weight 66104.6 (the details in Structural Details Page) Authors Blair, J.A. , Apsel, B. , Knight, Z.A. , Shokat, K.M. (deposition date : 2008-09-25, release date : 2008-10-14, last modified : 2011-07-13) Primary citation Apsel, B. , Blair, J.A. , Gonzalez, B. , Nazif, T.M. , Feldman, M.E. , Aizenstein, B. , Hoffman, R. , Williams, R.L. , Shokat, K.M. , Knight, Z.A. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol., 4:691 - 699, 2008.(PubMed : 18849971)  (DOI: 10.1038/nchembio.117) Experimental method X-RAY DIFFRACTION ( 2.66[Å] ) Other Database Information EM Navigator , Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P00523 ) , eF-site , KEGG (EC 2.7.10.2 ) , GDB , ProTherm , EzCatDB , PISA , PQS , wwPDB/RDF

Electron density map is available to be displayed.

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