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MineSummary [3i5s]

Summary Structural Experimental Function Sequence Neighbor Download Link

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PDB ID3i5s  sequence information (FASTA format)   
RELATED PDB ID3i5r
DescriptorPhosphatidylinositol 3-kinase regulatory subunit alpha
TitleCrystal structure of PI3K SH3
Functional KeywordsSH3 domain, Disease mutation, Host-virus interaction, Phosphoprotein, SH2 domain, PROTEIN BINDING
Biological sourceHomo sapiens (human)
Organ source [UNP - P27986] Skeletal muscle
[UNP - P27986] Brain
[UNP - P27986] Placenta, and Skeletal muscle
[UNP - P27986] Mammary epithelium
[UNP - P27986] Lung carcinoma
Total number of polymer chains4
Total molecular weight37841.7 (the details in Structural Details Page)
AuthorsBatra-Safferling, R. , Granzin, J. , Modder, S. , Hoffmann, S. , Willbold, D. (deposition date : 2009-07-06, release date : 2010-03-02)
Primary citationBatra-Safferling, R. , Granzin, J. , Modder, S. , Hoffmann, S. , Willbold, D.
Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding.
Biol.Chem., 391:33 - 42, 2010.(PubMed : 19919182)  (DOI: 10.1515/BC.2010.003)
Experimental methodX-RAY DIFFRACTION ( 3.000[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P27986 ) , eF-site , PISA , wwPDB/RDF


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