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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>
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PDB ID3l6f  sequence information (FASTA format)   
DescriptorHLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, Melanoma antigen recognized by T-cells 1
TitleStructure of MHC class II molecule HLA-DR1 complexed with phosphopeptide MART-1
Functional KeywordsMHC class II, HLA-DR1, phosphopeptide, Disulfide bond, Glycoprotein, Immune response, Membrane, MHC II, Transmembrane, Endoplasmic reticulum, Golgi apparatus, IMMUNE SYSTEM-PEPTIDE BINDING PROTEIN complex
IMMUNE SYSTEM/PEPTIDE BINDING PROTEIN
Biological sourceHomo sapiens (human)
Cellular location [UNP - P01903] Cell membrane; Single-pass type I membrane protein
[UNP - Q16655] Endoplasmic reticulum membrane; Single-pass type III membrane protein
Organ source [UNP - P01903] Blood, and Colon
[UNP - P01903] B-cell
[UNP - P01903] Blood
[UNP - P01903] Liver
[UNP - P04229] Cerebellum
[UNP - Q16655] Melanoma
[UNP - Q16655] Skin
Total number of polymer chains3
Total molecular weight45268.1 (the details in Structural Details Page)
AuthorsLi, Y. , Mariuzza, R.A. (deposition date : 2009-12-23, release date : 2010-05-12, last modified : 2010-07-28)
Primary citationLi, Y. , Depontieu, F.R. , Sidney, J. , Salay, T.M. , Engelhard, V.H. , Hunt, D.F. , Sette, A. , Topalian, S.L. , Mariuzza, R.A.
Structural Basis for the Presentation of Tumor-Associated MHC Class II-Restricted Phosphopeptides to CD4(+) T Cells.
J.Mol.Biol., 399:596 - 603, 2010.(PubMed : 20417641)  (DOI: 10.1016/j.jmb.2010.04.037)
Experimental methodX-RAY DIFFRACTION ( 2.10[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01903, P04229, Q16655 ) , eF-site , PISA , wwPDB/RDF



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