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Summary [3l9j]

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PDB ID or Keywordsequenceauthor nameEMDB ID

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PDB ID 3l9j  sequence information (FASTA format)    Descriptor TNFalpha, Tumor necrosis factor, soluble form Title Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex Functional Keywords TNF-alpha, antagonist, in vitro selection, Cell membrane, Cytokine, Disulfide bond, Glycoprotein, Lipoprotein, Secreted, Signal-anchor, Transmembrane, IMMUNE SYSTEM Biological source Homo sapiens (human) Cellular location [UNP - P01375] Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted Organ source [UNP - P01375] Blood [UNP - P01375] Prostatic carcinoma Total number of polymer chains 2 Total molecular weight 31836.4 (the details in Structural Details Page) Authors Byla, P. , Andersen, M.H. , Thogersen, H.C. , Gad, H.H. , Hartmann, R. (deposition date : 2010-01-05, release date : 2010-02-23, last modified : 2010-04-21) Primary citation Byla, P. , Andersen, M.H. , Holtet, T.L. , Jacobsen, H. , Munch, M. , Gad, H.H. , Thogersen, H.C. , Hartmann, R. Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex J.Biol.Chem., 285:12096 - 12100, 2010.(PubMed : 20179326)  (DOI: 10.1074/jbc.M109.063305) Experimental method X-RAY DIFFRACTION ( 2.100[Å] ) Other Database Information EM Navigator , Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01375 ) , eF-site , GDB , ProTherm , EzCatDB , PISA , PQS , wwPDB/RDF

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