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HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, HLA class II histocompatibility antigen gamma chain
Title
Crystal Structure of HLA-DR1 with CLIP106-120, flipped peptide orientation
Functional Keywords
MHC class II, MHC II, immune system, self antigen, invariant chain, CLIP IMMUNE SYSTEM
Biological source
Homo sapiens
(human)
Cellular location
[UNP - P01903]
Cell membrane; Single-pass type I membrane protein
[UNP - P04233]
Cell membrane; Single-pass type II membrane protein (Potential)
Gunther, S. , Schlundt, A. , Sticht, J. , Roske, Y. , Heinemann, U. , Wiesmuller, K.-H. , Jung, G. , Falk, K. , Rotzschke, O. , Freund, C.
(deposition date : 2010-11-01, release date : 2010-12-08, last modified : 2011-01-05)
Primary citation
Gunther, S. , Schlundt, A. , Sticht, J. , Roske, Y. , Heinemann, U. , Wiesmuller, K.H. , Jung, G. , Falk, K. , Rotzschke, O. , Freund, C. Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc.Natl.Acad.Sci.USA,
107:22219 - 22224, 2010.(PubMed : 21115828)(DOI: 10.1073/pnas.1014708107)
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