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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>
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PDB ID4aen  sequence information (FASTA format)   
RELATED PDB ID1d6e, 1kg0, 1iie, 1d5m, 1icf, 1hxy, 1lo5, 1seb, 1jws, 1h15, 2seb, 1sjh, 1fv1, 1jwm, 2xn9, 1klu, 1fyt, 1ymm, 1zgl, 1j8h, 1l3h, 1muj, 1t5w, 1d5x, 1klg, 2g9h, 1aqd, 1dlh, 1sje, 1d5z, 1jwu, 1t5x, 1a6a, 4ah2
DescriptorHLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1-1 BETA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN
TitleHLA-DR1 with covalently linked CLIP106-120 in reversed orientation
Functional KeywordsIMMUNE SYSTEM, SELF ANTIGEN, INVARIANT CHAIN, CLIP
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - P01903] Cell membrane; Single-pass type I membrane protein
[UNP - P04233] Cell membrane; Single-pass type II membrane protein (Potential)
Organ source [UNP - P01903] Blood, and Colon
[UNP - P01903] B-cell
[UNP - P01903] Blood
[UNP - P01903] Liver
[UNP - P04229] Cerebellum
[UNP - P04233] Heart, and Synovium
[UNP - P04233] B-cell, and Tonsil
[UNP - P04233] B-cell lymphoma
Total number of polymer chains3
Total molecular weight48305.8 (the details in Structural Details Page)
AuthorsSchlundt, A. , Guenther, S. , Sticht, J. , Wieczorek, M. , Roske, Y. , Heinemann, U. , Freund, C. (deposition date : 2012-01-11, release date : 2012-08-01, last modified : 2012-10-10)
Primary citationSchlundt, A. , Gunther, S. , Sticht, J. , Wieczorek, M. , Roske, Y. , Heinemann, U. , Freund, C.
Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex.
J.Mol.Biol., 423:294 - , 2012.(PubMed : 22820093)  (DOI: 10.1016/J.JMB.2012.07.008)
Experimental methodX-RAY DIFFRACTION ( 2.200[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01903, P04229, P04233 ) , eF-site , PISA , wwPDB/RDF



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