EnglishJapanese Previous Workshop Statistics Help FAQ Contact Us
Educational service >>
Download >>

PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.

Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
4e41.jpg
More images...
View in 3D molecule viewer
( jV4 / Jmol ) *1
<Biological unit>
jv_4e41.jpg
View in 3D molecule viewer
( jV4 ) *1
PDB ID4e41  sequence information (FASTA format)   
RELATED PDB ID4e42
DescriptorHLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, Triosephosphate isomerase (E.C.5.3.1.1), T cell receptor G4 alpha chain, T cell receptor G4 beta chain
TitleStructural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Functional KeywordsIg domain, adaptive immunity, T cell receptor, MHC, IMMUNE SYSTEM
Biological sourceHomo sapiens (human)
Cellular location [UNP - P01903] Cell membrane; Single-pass type I membrane protein
Organ source [UNP - P01903] Blood, and Colon
[UNP - P01903] B-cell
[UNP - P01903] Blood
[UNP - P01903] Liver
[UNP - P04229] Cerebellum
[UNP - P60174] Brain, Kidney, Placenta, Prostate, Skeletal muscle, Skin, and Uterus
[UNP - P60174] Skeletal muscle
[UNP - P60174] Mammary carcinoma
[UNP - P60174] Colon carcinoma
[UNP - P60174] Brain, Cajal-Retzius cell, and Fetal brain cortex
[UNP - P60174] Cervix carcinoma
[UNP - P60174] Pituitary
[UNP - P60174] Embryonic kidney
[UNP - P60174] T-cell
[UNP - P60174] Leukemic T-cell
Total number of polymer chains10
Total molecular weight189134.2 (the details in Structural Details Page)
AuthorsDeng, L. , Langley, R.J. , Wang, Q. , Topalian, S.L. , Mariuzza, R.A. (deposition date : 2012-03-11, release date : 2012-08-29)
Primary citationDeng, L. , Langley, R.J. , Wang, Q. , Topalian, S.L. , Mariuzza, R.A.
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, : - , 2012.
Experimental methodX-RAY DIFFRACTION ( 2.60[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01903, P04229, P60174 ) , eF-site , KEGG (EC 5.3.1.1 ) , PISA , wwPDB/RDF



*1) jV4 and Jmol require Java(TM)Plug-in 1.5 or later.
     Currently, you can't browse web pages which include jV applets in some version of Mac OS X. See here for more details.