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MineSummary [4tsv]

Summary Structural Experimental Function Sequence Neighbor Download Link

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PDB ID4tsv  sequence information (FASTA format)   
DescriptorTUMOR NECROSIS FACTOR-ALPHA
TitleHIGH RESOLUTION CRYSTAL STRUCTURE OF A HUMAN TNF-ALPHA MUTANT
Functional KeywordsLYMPHOKINE, TNF
Biological sourceHomo sapiens (human)
Cellular location [UNP - P01375] Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted
Organ source [UNP - P01375] Blood
[UNP - P01375] Prostatic carcinoma
Total number of polymer chains1
Total molecular weight16579 (the details in Structural Details Page)
AuthorsCha, S.-S. , Kim, J.-S. , Cho, H.-S. , Oh, B.-H. (deposition date : 1997-10-29, release date : 1998-12-30, last modified : 2011-07-13)
Primary citationCha, S.S. , Kim, J.S. , Cho, H.S. , Shin, N.K. , Jeong, W. , Shin, H.C. , Kim, Y.J. , Hahn, J.H. , Oh, B.H.
High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity.
J.Biol.Chem., 273:2153 - 2160, 1998.(PubMed : 9442056)  (DOI: 10.1074/jbc.273.4.2153)
Experimental methodX-RAY DIFFRACTION ( 1.8[Å] )
Other Database Information
Yorodumi , CATH , FSSP , SCOP , VAST , UniProt ( P01375 ) , eF-site , PISA , wwPDB/RDF


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